产品货号：
Z21885
中文名称：
NFIB抗体
英文名称：
Anti-NFIB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NFIB Antibody |
| 指标别名 | nuclear factor I B;CTF;HMGIC/NFIB;MACID;NF-I/B;NF1-B;NFI-B;NFI-RED2;NFIB3;NFIB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | NFIB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human NFIB/NF1B2 (ELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQR). |
| 实际分子量 | 47KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene.The NFIB gene is a part of the NFI gene complex that includes three other genes (NFIA,NFIC and NFIX).The NFIB gene is a protein coding gene that also serves as a transcription factor.This gene is essential in embryonic development and it works together with its gene complex to initiate tissue differentiation in the fetus.Through knockout experiments,researchers found that mice without the NFIB gene have severely underdeveloped lungs.This mutation does not seem to cause spontaneous abortions because in utero the fetus does not use its lungs for respiration.However,this becomes lethal once the fetus is born and has to take its first breath.It is thought that NFIB plays a role in down regulating the transcription factors TGF-β1 and Shh in normal gestation because they remained high in knockout experiments.The absence of NFIB also leads to insufficient amounts of surfactant being produced which is one reason why the mice cannot breathe once it is born.The knockout experiments demonstrated that NFIB has a significant role in fore-brain development.NFIB is typically found in pontine nuclei of the CNS,the cerebral cortex and the white matter of the brain and without NFIB these areas are dramatically affected. |
| Uniprot ID | O00712 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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